Second presentation on #ResearchMisconduct Alexander Wlodawer looking in detail at careless and rare fake structures in Crystallography and CryEM @FEBSnews
Wlodawer: several examples of structures deposited but not published, even many years later #ProteinStructure
Wlodawer: made three attempts to get editors (n=3) to retract a clearly erroneous structure - no response #PublicationEthics
Wlodawer: "successful" attempts to get retractions may include phrasing that says eg "this correction should note impact on the validity of other data in the paper"
Wlodawer: if you can remove the structure, and the rest of the paper is fine, then begs question why structure was in paper in first place #PublicationEthics
Wlodawer: #CryoEM emerging as important new technique, are the specialists in this field learning from the errors made in history of crystallography? #StructuralBiology
Wlodawer: people are claiming unrealistic resolution quality in #cryoEM maps
Wlodawer: there are also issues and inconsistency about whether the #cryoEM map/structure deposited is the original or sharpened data
Stell: Scientists are not the only people whose work relies on accuracy of published work - also basis for current and future research, public policy, etc #ResearchMisconduct
Stell: cites the #Poldermans case and how flawed publication that made its way into guidelines led to 8000 deaths