Alexis Verger Profile picture
Sep 24, 2018 16 tweets 9 min read Twitter logo Read on Twitter
Because I do believe that it's important to know the history of your field and inspired by @carlzimmer @matthewcobb & Michel Morange's books that contain some fantastic material for teaching, a thread with some #classicpaper in #molecularbiology #DNA
1⃣ 1944 Oswald Avery, Colin MacLeod & Maclyn McCarty - DNA, not protein as was commonly believed, is the hereditary material for bacteria, and the cause of bacterial transformation…
2⃣ 1947 André Boivin & Roger Vendrely - a near forgotten 2 pages in French that suggest almost explicitly that DNA --> RNA --> protein…
3⃣ 1952 & 1953 Alexander Dounce - like Boivin & Vendrely, Dounce is one of the first to propose that DNA might serve as a template for the synthesis of RNA, which in turn serves as a template for the synthesis of proteins…
4⃣ 1952 Alfred Hershey & Martha Chase - They confirmed that DNA was the molecule of heredity a.k.a as the blender experiment
5⃣ 1953 The structure of DNA - Watson & Crick…, Franklin & Gosling…, Wilkins Stokes Wilson…
6⃣ 1956 & 1958 Francis Crick - The Central Dogma: once ‘information’ is passed into protein it cannot get out again…
7⃣ NOT the Central Dogma DNA -> RNA -> Protein (for more info see…)
8⃣ 1958 Francis Crick - The adaptor hypothesis: to explain how information encoded in DNA is used to specify the amino acid sequence of proteins…
9⃣ 1958 Mahlon Hoagland - discovery of the adaptors = soluble RNAs a.k.a. tRNA
1⃣0⃣ Vernon Ingram - The first demonstration that the abnormal haemoglobin in sickle cell anaemia patients is caused by an alteration in one amino acid…
1⃣1⃣ 1958 Matthew Meselson and Franklin W. Stahl - experimental proof of Semi-Conservative DNA Replication…
1⃣2⃣1959 Pardee, Jacob & Monod… a.k.a The PaJaMo experiment that supported the hypothesis that a molecule mediated the production of proteins from DNA (cytoplasmic messenger)
1⃣3⃣ 1961 Jacob & Monod - the fundamental basis of gene regulation, one of the most influential paper in the history of modern biology (& I am not saying that because Jacob & Monod were French 😬)…
1⃣4⃣ 1961 Brenner, Jacob, Meselson… + Gros, Hiatt, Gilbert, Kurland, Risebrough, Watson… the discovery of messenger RNA (mRNA)
1⃣5⃣ for an historical point of view of the discovery of mRNA, see also this great recount by @matthewcobb…

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