Alexis Verger Profile picture
Sep 24, 2018 16 tweets 9 min read Twitter logo Read on Twitter
Because I do believe that it's important to know the history of your field and inspired by @carlzimmer @matthewcobb & Michel Morange's books that contain some fantastic material for teaching, a thread with some #classicpaper in #molecularbiology #DNA
1⃣ 1944 Oswald Avery, Colin MacLeod & Maclyn McCarty - DNA, not protein as was commonly believed, is the hereditary material for bacteria, and the cause of bacterial transformation jem.rupress.org/content/79/2/1…
2⃣ 1947 André Boivin & Roger Vendrely - a near forgotten 2 pages in French that suggest almost explicitly that DNA --> RNA --> protein link.springer.com/article/10.100…
3⃣ 1952 & 1953 Alexander Dounce - like Boivin & Vendrely, Dounce is one of the first to propose that DNA might serve as a template for the synthesis of RNA, which in turn serves as a template for the synthesis of proteins nature.com/articles/17254…
4⃣ 1952 Alfred Hershey & Martha Chase - They confirmed that DNA was the molecule of heredity jgp.rupress.org/content/36/1/39 a.k.a as the blender experiment
5⃣ 1953 The structure of DNA - Watson & Crick nature.com/articles/17173…, Franklin & Gosling nature.com/articles/17174…, Wilkins Stokes Wilson nature.com/articles/17173…
6⃣ 1956 & 1958 Francis Crick - The Central Dogma: once ‘information’ is passed into protein it cannot get out again profiles.nlm.nih.gov/ps/retrieve/Re…
7⃣ NOT the Central Dogma DNA -> RNA -> Protein (for more info see judgestarling.tumblr.com/post/177554581…)
8⃣ 1958 Francis Crick - The adaptor hypothesis: to explain how information encoded in DNA is used to specify the amino acid sequence of proteins en.wikipedia.org/wiki/Adaptor_h…
9⃣ 1958 Mahlon Hoagland - discovery of the adaptors = soluble RNAs a.k.a. tRNA ncbi.nlm.nih.gov/pubmed/13538965
1⃣0⃣ Vernon Ingram - The first demonstration that the abnormal haemoglobin in sickle cell anaemia patients is caused by an alteration in one amino acid nature.com/articles/18032…
1⃣1⃣ 1958 Matthew Meselson and Franklin W. Stahl - experimental proof of Semi-Conservative DNA Replication pnas.org/content/44/7/6…
1⃣2⃣1959 Pardee, Jacob & Monod sciencedirect.com/science/articl… a.k.a The PaJaMo experiment that supported the hypothesis that a molecule mediated the production of proteins from DNA (cytoplasmic messenger)
1⃣3⃣ 1961 Jacob & Monod - the fundamental basis of gene regulation, one of the most influential paper in the history of modern biology (& I am not saying that because Jacob & Monod were French 😬) sciencedirect.com/science/articl…
1⃣4⃣ 1961 Brenner, Jacob, Meselson nature.com/articles/19057… + Gros, Hiatt, Gilbert, Kurland, Risebrough, Watson nature.com/articles/19058… the discovery of messenger RNA (mRNA)
1⃣5⃣ for an historical point of view of the discovery of mRNA, see also this great recount by @matthewcobb cell.com/current-biolog…

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Alexis Verger

Alexis Verger Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(