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Prof Darrel Francis ☺ Mk CardioFellows Great Again Profile picture
@ProfDFrancis
Nov 25, 2017 • 47 tweets • 14 min read • Read on X
Considering #statin in 35-y-o man worried about extensive family history of MI+stroke: 2 parents, 3 of 4 sibs.

#Cholesterol 5.8 mM, 224 mg/dl. Subtypes typical for such a total.
Non-smoker. Otherwise average.

[Live-quiz from #orbita-HQ for #cardioTwitter fellows & the curious]
Question C2.

First vote was for diet first, and quite right too! That is the guideline, and we must obey.

Natural, organic, eco-friendly and therefore best.

What effect size is a reasonable expectation, for patient and Dr, for the reduction of total cholesterol by diet?

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More from @ProfDFrancis

Prof Darrel Francis ☺ Mk CardioFellows Great Again Profile picture
Jul 29, 2018
If anyone wants to know how incorrect causal inference arises in cardiology, there's no need to do a PhD on it.

It's encapsulated in this thread. Unlike most of my threads it has a happy ending though !

First, a whole load of unsuspecting patients have PCI.
Then a bunch of cardiologists who are normally ultracompetitive decide to do something constructive for a change, instead of just doing each other down in cross-London acrimony.

Let's get together and ...

google.co.uk/url?sa=t&sourc…
They do what we always do when we cardiologists get together. Tell stories.

"I had a guy with 3 vessel thrombosis in cardiogenic shock, going into asystole as he was put on the table, but we still saved him!"
Read 64 tweets
Prof Darrel Francis ☺ Mk CardioFellows Great Again Profile picture
May 27, 2018
How to make your
correlations correlate.
Even if they don't.
==============

A practical tweetorial for aspiring research fraudsters, cardiology fellows doing research, and others in need of a strong association when there isn't one.

#meded #foamed

Please retweet to fellows.
Thank you to @rallamee for loaning me the use of her garden and boating lake to do a few demonstrations in this weekend's tweetorial.
Thank you also to a colleague, for sending me this just now. It is enlightening and I am genuinely sorry.
Read 58 tweets
Prof Darrel Francis ☺ Mk CardioFellows Great Again Profile picture
May 13, 2018
Summer Sunday quiz
-----------------------

from Sunny Plymouth, Pearl of Europe

#DreadMed #DooMed
Look at this table of baseline characteristics.

Control arm consists of 22+2 = 24 people.
Therapy arm consists of 20+1=21 people.
How many people is that, altogether?
Read 24 tweets
Prof Darrel Francis ☺ Mk CardioFellows Great Again Profile picture
May 13, 2018
Joel Giblett @joelgiblett brings up a very important question.

Where does scientific integrity come from? What makes me think I can trust papers written by him? I've never heard of him before this tweet, and I have no idea of his background.
Well, first of all, he seems genuinely curious about integrity. This is a good sign.

Second, he is scared of R&D and MHRA. This is a good sign that he tries to toe the line, pays his taxes, doesn't park in the disabled spots (unless entitled) and doesn't drop litter.
But it is not non-littering, or trembling when the R&D office sends an email, that CAUSES his research to be non-fake.

It is his own personal attitude, those of his colleagues, and the lack of tremendous incentives to fiddle.
Read 22 tweets
Prof Darrel Francis ☺ Mk CardioFellows Great Again Profile picture
Apr 21, 2018
Risk Ratio, Odds Ratio, Hazard Ratio
========================

2nd and final part of the tweetorial, from ORBITA-HQ!

Fun, easy and informative [*]

#MedEd #FOAMed #cardiology #cardiotwitter
[*] Results may vary and are not guaranteed. See small print.

Not all fears are alike.

* Some fears are one-and-done:
I get a cold which progresses to pneumonia. Will I die, or recover?

* Other things hang over us for much longer, perhaps all your life.
Will you get hit by a bus?
Get a heart attack?
There's no "sell by" date on the fear.
Practice Qs

You are walking through Hyde park, minding your own business.
Hardly causing any trouble at all.
Perhaps the odd humorous tweet.

You get a Direct Message:
"Enough of ur abuse!
You will be hearing form my agent shortly.
kthxbai
AJ Kirtane"

You see the agent:
Read 89 tweets
Prof Darrel Francis ☺ Mk CardioFellows Great Again Profile picture
Apr 13, 2018
Can you get into the mindset of a probability?

You thought you had a simple and easy life, roaring along the highway from 0 upwards.

Until you see this ahead of you.
You have a twin sister, who in her youth was similar to you in many respects.
But she was always more vivacious and sporty.

When you read comic books, she preferred to dance.

When you watched TV, she joined a cycling club.

Now you are almost at a dead end.
And she is running free.
Read 30 tweets

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