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1/ No history of vaccination should begin with Jenner. The practice of inoculation is a necessary precursor to any history of vaccination, but often gets left behind, diminished or derided. Not to mention Benjamin Jesty. #historyisnotGreatMen #histmed #histSTM (thread)
2/ Smallpox has been with us possibly since the Neolithic Revolution. And at least since the 16th century, variolation (or insufflation (blowing dried smallpox matter into the nose) was routinely practiced as a preventive in China. And that is based on written records alone. 
3/ In India from the 17th century onwards, there is written evidence of variolation, or dipping a sharp iron needle into dried smallpox matter and puncturing the skin in a small circle, usually on the upper arm. Practiced during the spring, variolation used 'pocky matter'....
