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Dr Gaetan Burgio, MD, PhD. Profile picture
Dr Gaetan Burgio, MD, PhD.
@GaetanBurgio
Group leader, Australian National University ANU, Australia. Geneticist working on infections & #CRISPR. Opinions and views ....
Aug 8, 2018 • 15 tweets • 7 min read
Finally the comments to Mitalipov’s group paper on #CRISPR in human embryos are out in @nature as well as the rebuttal from Ma et al. as brief communications arising #paywall. Let’s have a look more in details -> Thread One of the major finding of the Ma et al. paper was the discovery of high frequency of inter-homologous repair mechanisms aka loss of heterozygocity LOH -> 1 allele is used as a template for
#CRISPR-HDR -> WT alleles are in fact alleles from the maternal alleles only.