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Finally the comments to Mitalipov’s group paper on #CRISPR in human embryos are out in @nature as well as the rebuttal from Ma et al. as brief communications arising #paywall. Let’s have a look more in details -> Thread
One of the major finding of the Ma et al. paper was the discovery of high frequency of inter-homologous repair mechanisms aka loss of heterozygocity LOH -> 1 allele is used as a template for
#CRISPR-HDR -> WT alleles are in fact alleles from the maternal alleles only.
#CRISPR-HDR -> WT alleles are in fact alleles from the maternal alleles only.
We have been debating a lot on this in the last year or so. The first important comment from @Fatwa_Adikusuma et al is Ma et al. missed deleted alleles. In the paper they edited 6 loci in zygotes and EScells and checked for large deletions nature.com/articles/s4158…
In case you haven't yet read @gailfdavies' fantastic tweets on the role of consultants in embedding a particular vision of 'flexible retirement' as the norm in universities, start with tweet below & then follow the tweets -- & links -- to the present #ucustrike #ussstrike
Inspired by @gailfdavies & @CLIVEYB's reflections, I've been thinking about how to understand the last decade or so in terms of discourses & practices around risk, collectivity, flexibility etc. in relation to university pensions #notallgeographers #USSstrike #ucustrike 1/
I've been tracking through the docs on pensions available on Universities UK website. Oldest document appears to be "Strategic enquiry into the pension arrangements for the higher education sector" published 2007 universitiesuk.ac.uk/policy-and-ana… 2/ #ussstrike #ucustrike
