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Now that the #epibookclub is over, my weekends are free for reading #RCTs. So, how about a #tweetorial about #pragmatic trials, causal questions, and #landmark analyses, inspired by the #SCOTHEART trial?
#epimethodsclub #cardiotwitter
#epimethodsclub #cardiotwitter
If we’re going to talk about #pragmatic trials, then we need to start with a definition. The simplest definition I’ve seen is from a trialist I interviewed for my recent @JClinEpi paper (authors.elsevier.com/a/1XS1b3BcJPuv…)
pRCTs “...attempt to address effectiveness in real world settings”
pRCTs “...attempt to address effectiveness in real world settings”
Sure, it’s a bit vague but it’s useful because, like Tolstoy’s unhappy families, #pragmatic trials are all different.
So, what makes me think #SCOTHEART is pragmatic?
My 2¢: lack of blinding, inclusion criteria based on symptoms not diagnoses, & standard care as comparator.
So, what makes me think #SCOTHEART is pragmatic?
My 2¢: lack of blinding, inclusion criteria based on symptoms not diagnoses, & standard care as comparator.
